We Offer Specialized and Standard Disease and Pharmacology Models
Hypertension and Blood Pressure
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- Radio-Telemetry – Continuous measurement of blood pressure, heart rate, ECG, respiration, activity and temperature in conscious, unrestrained animals for up to 6 months
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- Tethered Model – Continuous measurement of blood pressure with simultaneous infusion of test compound along with blood, urine and/or fecal collection for up to 10 days
Species: Rat, Mouse and Guinea Pig
Disease Models: SHR, Dahl Salt Sensitive (DSS), ZSF1, ANGII-induced (additional models available)
Nephropathy
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- Proteinuria, albuminuria, GFR, Creatinine Clearance, histological evaluation
- Plasma/Urine Biomarkers of damage
- Chronic blood pressure monitoring using radio telemetry
Disease Models: 5/6 Nephrectomy, Renal Ischemia/Reperfusion, Dahl Salt Sensitive (DSS), Streptozotocin (STZ), ZSF1, Unilateral Urethral Obstruction (UUO), Puromycin Aminonucleoside (PAN), Uninephrectomized (additional models available)
Heart Failure
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- Left Ventricular Function, Cardiac remodeling and Histological evaluation
Methods: Echocardiography (M-Mode, B-Mode & Doppler), Pressure/Volume, Invastive LV Hemodynamics (+/-dP/dT, Tau, LVEDP and LVESP)
Disease Models: Myocardial Infarction, ZSF1, SHHF, Dahl Salt Sensitive (DSS) (additional models available)
Liver Fibrosis
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- Collagen/Hydroxyproline content
- Serum ALT/AST/ALP
- Portal Vein Pressure
- Histological evaluation
Models: Carbon Tetrachloride (CCl4) and Bile Duct Ligation (BDL)
Pulmonary Arterial Hypertension
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- Right Ventricular Systolic Pressure/Pulmonary Arterial Pressure
- Heart and Lung Weight
- Myocardial, Pulmonary Artery and Lung Histology
Disease Models: Monocrotaline PAH
Metabolic
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- Glucose and Insulin Tolerance Tests (OGTT/IPGTT)
- Fasting and fed blood glucose
- Cholesterol, HDL, LDL, Apolipoproteins, HbA1C, Microalbumin, Creatinine, etc.
- Adipose tissue and body weight
Disease Models: Type I and II diabetes – ob/ob, db/db, DIO and STZ mice; ZDF and STZ rats (additional models available)
Microscopy & Histology
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- We offer a wide range of microscopy and histology services to enable detailed quantitative organ/tissue analysis and morphometry
- Fixation and processing of samples into paraffin, OCT and plastic
- Sectioning and staining of tissue blocks for LM histology and EM ultrastructure
- Range of quantitative microscopy techniques including; Epi-fluorescence, Laser scanning & capture, Electron microscopy