We Offer Specialized and Standard Disease and Pharmacology Models

Hypertension and Blood Pressure

• • Radio-Telemetry – Continuous measurement of blood pressure, heart rate, ECG, respiration, activity and temperature in conscious, unrestrained animals for up to 6 months

• • Tethered Model – Continuous measurement of blood pressure with simultaneous infusion of test compound along with blood, urine and/or fecal collection for up to 10 days

Species: Rat, Mouse and Guinea Pig

Disease Models: SHR, Dahl Salt Sensitive (DSS), ZSF1, ANGII-induced (additional models available)

Nephropathy

• • Proteinuria, albuminuria, GFR, Creatinine Clearance, histological evaluation
  • Plasma/Urine Biomarkers of damage
  • Chronic blood pressure monitoring using radio telemetry

Disease Models: 5/6 Nephrectomy, Renal Ischemia/Reperfusion, Dahl Salt Sensitive (DSS), Streptozotocin (STZ), ZSF1, Unilateral Urethral Obstruction (UUO), Puromycin Aminonucleoside (PAN), Uninephrectomized (additional models available)

Heart Failure

• • Left Ventricular Function, Cardiac remodeling and Histological evaluation

Methods: Echocardiography (M-Mode, B-Mode & Doppler), Pressure/Volume, Invastive LV Hemodynamics (+/-dP/dT, Tau, LVEDP and LVESP)

Disease Models: Myocardial Infarction, ZSF1, SHHF, Dahl Salt Sensitive (DSS) (additional models available)

Liver Fibrosis

• • Collagen/Hydroxyproline content
  • Serum ALT/AST/ALP
  • Portal Vein Pressure
  • Histological evaluation

Models: Carbon Tetrachloride (CCl4) and Bile Duct Ligation (BDL)

Pulmonary Arterial Hypertension

• • Right Ventricular Systolic Pressure/Pulmonary Arterial Pressure
  • Heart and Lung Weight
  • Myocardial, Pulmonary Artery and Lung Histology

Disease Models: Monocrotaline PAH

Metabolic

• • Glucose and Insulin Tolerance Tests (OGTT/IPGTT)
  • Fasting and fed blood glucose
  • Cholesterol, HDL, LDL, Apolipoproteins, HbA1C, Microalbumin, Creatinine, etc.
  • Adipose tissue and body weight

Disease Models: Type I and II diabetes – ob/ob, db/db, DIO and STZ mice; ZDF and STZ rats (additional models available)

Microscopy & Histology

• • We offer a wide range of microscopy and histology services to enable detailed quantitative organ/tissue analysis and morphometry
  • Fixation and processing of samples into paraffin, OCT and plastic
  • Sectioning and staining of tissue blocks for LM histology and EM ultrastructure
  • Range of quantitative microscopy techniques including; Epi-fluorescence, Laser scanning & capture, Electron microscopy